Telomeres, Sirtuins and NAD+ ---- The Genetic Communication at the Ends

Telomeres, Sirtuins and NAD+ are all implicated in the aging process. Telomeres are repeating nucleoprotein sequences found at the ends of chromosomes. Sirtuins regulate telomere length by localizing to telomeres. A decrease in NAD+ levels as aging progresses has been demonstrated by many clinical studies. An understanding of shortening of telomere leads to suppression in Sirtuin activity as well as decrease in NAD+ and vice versa, suggesting interlinking of their pathways. The positive effects of NAD+ on the aging phenotype are partially assumed to be attributed to Sirtuins. Data was collected by selecting 42 articles by searching through keywords; Telomeres, p53, Sirtuins, NAD+, aging, age-related diseases, genomic stability, Sirtuin activation, in search engines like google scholar and PubMed. The purpose of this review was to find out the functional linking between NAD+, Sirtuins and telomeres length which can help in future studies to improve the therapy options for possible age associated diseases.

Telomeres, p53, Sirtuins, NAD+, aging, age-related diseases, genomic stability, Sirtuin activation.